Quest Items page for a list of keys, where they are found, and the doors they unlock.
Runes are found in sealed small rune and big small rune variants, and you will need to locate the NPC Crafter to break the seal and reveal the runes inside. Runes are then placed in items with sockets.
You can remove a rune from an item at the crafter
combat page for details on this and energy management.
Spell Points or Attribute Points. Every time you point a point into an attribute you level up. You must level up at a checkpoint and you must have enough experience to do so.
To find him you have 3 way's to go, and you need to go by 2 of them to use the lever which gives you acces to another quest mission and final lord fight.
1st one is to kill a boss called Guardian and then wreck everything in the maze to find the lever.
2nd one is when you had a checkpoint just near the cave with the spiders and pitfalls.
3rd one is after Infiltrator fight. You will have a big doors which opens a part of quest.
From 2nd and 3rd you can get to a 2nd lever and you can access Annihilator from there.